HSCT-TMA | Spot The Signs

Can you spot the signs of HSCT-TMA before it’s too late?

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For patients with hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA), also known as transplant-associated TMA (TA-TMA), delayed diagnosis may cause severe consequences and premature mortality.^1-3

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GvHD, graft-versus-host disease; LDH, lactate dehydrogenase; sC5b-9, soluble complement 5b-9.

Meri S, Bunjes D, Cofiell R, Jodele S. The role of complement in HSCT-TMA: basic science to clinical practice. Adv Ther. 2022;39(9):3896-3915.

Jodele S, Dandoy CE, Sabulski A, et al. Transplantation-associated thrombotic microangiopathy risk stratification: is there a window of opportunity to improve outcomes? Transplant Cell Ther. 2022;28(7):392.e1-392.e9.

Jodele S, Laskin BL, Dandoy CE, et al. A new paradigm: diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury. Blood Rev. 2015;29(3):191-204.